Type-1 metabotropic glutamate receptor signaling in cerebellar Purkinje cells in health and disease

F1000Res. 2017 Apr 4;6:416. doi: 10.12688/f1000research.10485.1. eCollection 2017.


The cerebellum is a brain structure involved in coordination, control, and learning of movements, as well as certain aspects of cognitive function. Purkinje cells are the sole output neurons from the cerebellar cortex and therefore play crucial roles in the overall function of the cerebellum. The type-1 metabotropic glutamate receptor (mGluR1) is a key "hub" molecule that is critically involved in the regulation of synaptic wiring, excitability, synaptic response, and synaptic plasticity of Purkinje cells. In this review, we aim to highlight how mGluR1 controls these events in Purkinje cells. We also describe emerging evidence that altered mGluR1 signaling in Purkinje cells underlies cerebellar dysfunctions in several clinically relevant mouse models of human ataxias.

Keywords: Purkinje cell; cerebellum; cognitive function; metabotropic glutamate receptor; signaling.

Publication types

  • Review

Grant support

This work was supported by the Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (grant 25000015), and the Brain/MINDS grant from the Japan Agency for Medical Research and Development.