Stereotactic body radiotherapy for pediatric hepatocellular carcinoma with central biliary obstruction

Pediatr Blood Cancer. 2017 Jun;64(6). doi: 10.1002/pbc.26330. Epub 2016 Nov 5.


Here, we present the case of a pediatric patient with newly diagnosed hepatocellular carcinoma causing central biliary obstruction and persistently elevated bilirubin of 3.0-4.3 mg/dl despite placement of bilateral internal-external biliary drains. The tumor was not resectable, and the patient was not a candidate for liver transplant due to nodal disease, for chemotherapy due to hyperbilirubinemia, or for local therapies aside from stereotactic body radiotherapy (SBRT). In this report, we discuss the successful use of SBRT in the management of this patient, and its role in allowing the patient to become a candidate for additional therapies.

Keywords: HCC; SBRT; hepatocellular carcinoma; stereotactic body radiotherapy.

Publication types

  • Case Reports

MeSH terms

  • Biliary Tract Diseases / blood
  • Biliary Tract Diseases / diagnostic imaging
  • Biliary Tract Diseases / radiotherapy
  • Bilirubin / blood*
  • Carcinoma, Hepatocellular* / blood
  • Carcinoma, Hepatocellular* / diagnostic imaging
  • Carcinoma, Hepatocellular* / radiotherapy
  • Child
  • Humans
  • Liver Neoplasms* / blood
  • Liver Neoplasms* / diagnostic imaging
  • Liver Neoplasms* / radiotherapy
  • Male
  • Radiosurgery*


  • Bilirubin