Two functionally and chemically distinct immunomodulatory compounds in the gel of Aloe vera

J Ethnopharmacol. 1988 May-Jun;23(1):61-71. doi: 10.1016/0378-8741(88)90115-8.


An aqueous extract of Aloe vera gel was analyzed guided by modulatory activity with regard to the in vitro activation of human complement and of human polymorphnuclear leucocytes (PMN). Upon ultrafiltration a high (h-Mr) and a low (l-Mr) molecular mass fraction were obtained. Pre-incubation of human pooled serum with the h-Mr fraction resulted in a depletion of classical and alternative pathway complement activity. In contrast, only the l-Mr fraction could inhibit the production of free oxygen radicals by activated PMNs. The latter activity cannot be attributed to non-specific effects like toxicity, interference with stimulant binding or scavenger activity.

MeSH terms

  • Adjuvants, Immunologic / isolation & purification*
  • Adjuvants, Immunologic / pharmacology
  • Aloe / chemistry
  • Aloe / immunology*
  • Complement Inactivator Proteins / isolation & purification
  • Gels
  • Humans
  • In Vitro Techniques
  • Neutrophils / immunology
  • Neutrophils / metabolism
  • Plants, Medicinal / immunology*
  • Superoxides / metabolism
  • Ultrafiltration


  • Adjuvants, Immunologic
  • Complement Inactivator Proteins
  • Gels
  • Superoxides