Lymphocyte activation by HIV-1 envelope glycoprotein

Nature. 1988 Sep 29;335(6189):445-8. doi: 10.1038/335445a0.


Cell activation by phytohaemagglutinin, phorbol ester and by the supernatant of phytohaemagglutinin-stimulated peripheral blood mononuclear cells induces the expression and cytopathic effects of latent human immunodeficiency virus type-1 (HIV-1) in vitro. The lymphocyte surface protein CD4 has been identified as a receptor for HIV-1 and binds the viral envelope glycoprotein (gp120). In the light of evidence indicating that one natural function of CD4 is as a growth factor receptor, we examined the ability of native gp120 to activate resting CD4-bearing lymphocytes. Our results indicate that gp120 has innate biological activity as a result of a specific interaction with CD4, inducing increases in intracellular levels of inositol trisphosphate and of calcium, and in interleukin-2 receptor expression and cell motility.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Calcium / blood
  • Chemotaxis, Leukocyte
  • HIV Envelope Protein gp120
  • HIV*
  • Humans
  • In Vitro Techniques
  • Inositol 1,4,5-Trisphosphate
  • Inositol Phosphates / biosynthesis
  • Lymphocyte Activation*
  • Receptors, HIV
  • Receptors, Immunologic / biosynthesis
  • Receptors, Interleukin-2
  • Receptors, Virus / physiology
  • Retroviridae Proteins / physiology*
  • T-Lymphocytes, Helper-Inducer / metabolism
  • T-Lymphocytes, Helper-Inducer / physiology*
  • Viral Envelope Proteins / physiology*


  • HIV Envelope Protein gp120
  • Inositol Phosphates
  • Receptors, HIV
  • Receptors, Immunologic
  • Receptors, Interleukin-2
  • Receptors, Virus
  • Retroviridae Proteins
  • Viral Envelope Proteins
  • Inositol 1,4,5-Trisphosphate
  • Calcium