A New Prognostic Instrument Specifically Designed for Patients Irradiated for Recurrent Carcinoma of the Bladder

In Vivo. 2017 May-Jun;31(3):435-438. doi: 10.21873/invivo.11079.

Abstract

Background/aim: To develop an instrument that could estimate the 1-year survival probabilities of patients irradiated for recurrent carcinoma of the bladder.

Patients and methods: Thirty patients irradiated for locally recurrent bladder carcinoma were included. Six pre-treatment factors [age, gender, Karnofsky score (KPS), pack years, grading and time between cancer diagnosis and radiotherapy] were evaluated for survival. Of those factors showing a trend or significance on multivariate analysis, 1-year survival rates were added.

Results: On multivariate analysis, KPS was significant (hazard ratio(HR)=3.76, p=0.008), age showed a trend (HR=2.04, p=0.13). Patient scores were five, nine, ten or fourteen points with 1-year survival rates of 13%, 25%, 57% and 82% (p=0.003). Three groups were designed, A (5-9 points), B (10 points) and C (14 points) with 1-year survival rates of 17%, 57% and 82% (p=0.001).

Conclusion: This score, including three groups with different 1-year survival probabilities, can aid physicians treating patients with recurrent bladder carcinoma.

Keywords: Locally recurrent carcinoma of the bladder; irradiation; pre-treatment factors; predictive score; survival.

MeSH terms

  • Aged
  • Carcinoma / pathology*
  • Female
  • Humans
  • Karnofsky Performance Status
  • Male
  • Multivariate Analysis
  • Neoplasm Recurrence, Local / pathology*
  • Prognosis
  • Survival Rate
  • Urinary Bladder / pathology*
  • Urinary Bladder Neoplasms / pathology*