Gestational bisphenol-A exposure lowers the threshold for autoimmunity in a model of multiple sclerosis

Proc Natl Acad Sci U S A. 2017 May 9;114(19):4999-5004. doi: 10.1073/pnas.1620774114. Epub 2017 Apr 24.

Abstract

Environmental and hormonal factors are implicated in dysimmunity in multiple sclerosis. We investigated whether bisphenol-A, a prominent contaminant with endocrine-disrupting capabilities, altered susceptibility in an inflammatory model of multiple sclerosis. We found that gestational, but not adult, exposure to bisphenol-A increased the development of experimental autoimmune encephalomyelitis in adulthood in male, but not female, mice when a suboptimal disease-inducing immunization was used. Gestational bisphenol-A in male mice primed macrophages in adulthood and raised granulocyte-colony stimulating factor and neutrophil counts/activity postsuboptimal immunization. Neutralizing granulocyte-colony stimulating factor blocked susceptibility to disease in bisphenol-A mice. Early life exposure to bisphenol-A may represent an environmental consideration in multiple sclerosis.

Keywords: bisphenol A; experimental autoimmune encephalomyelitis; gestational exposure; innate immunity; multiple sclerosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autoimmunity / drug effects*
  • Benzhydryl Compounds / toxicity*
  • Disease Models, Animal
  • Encephalomyelitis, Autoimmune, Experimental* / chemically induced
  • Encephalomyelitis, Autoimmune, Experimental* / immunology
  • Encephalomyelitis, Autoimmune, Experimental* / pathology
  • Female
  • Male
  • Mice
  • Multiple Sclerosis* / chemically induced
  • Multiple Sclerosis* / immunology
  • Multiple Sclerosis* / pathology
  • Phenols / toxicity*
  • Pregnancy
  • Prenatal Exposure Delayed Effects* / chemically induced
  • Prenatal Exposure Delayed Effects* / immunology
  • Prenatal Exposure Delayed Effects* / pathology

Substances

  • Benzhydryl Compounds
  • Phenols
  • bisphenol A

Grant support