Parsonage-Turner syndrome due to autochthonous acute genotype 3f hepatitis E virus infection in a nonimmunocompromised 55-year-old patient

J Neurovirol. 2017 Aug;23(4):615-620. doi: 10.1007/s13365-017-0525-0. Epub 2017 Apr 24.


Hepatitis E virus (HEV) infection is an emerging autochthonous disease in industrialized countries. Extra-hepatic manifestations, in particular neurologic manifestations, have been reported in HEV infection. Only a few cases of hepatitis E-associated Parsonage-Turner syndrome have been reported, and HEV genotypes were rarely determined. Here, we report the case of a Parsonage-Turner syndrome associated with an acute autochthonous HEV infection in a 55-year-old immunocompetent patient. HEV genomic RNA was detected in serum and cerebrospinal fluid samples (CSF), and molecular phylogenetic analysis of HEV was performed. The interest of this case lies in its detailed description notably the molecular analysis of HEV RNA isolated from serum and CSF. HEV infection should be considered in diagnostic investigations of neurologic manifestations associated with liver function perturbations.

Keywords: Hepatitis E; Neuralgic amyotrophy; Neurological disorders; Parsonage-Turner syndrome.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Brachial Plexus Neuritis / diagnosis*
  • Brachial Plexus Neuritis / etiology
  • Brachial Plexus Neuritis / pathology
  • Brachial Plexus Neuritis / virology
  • Genotype*
  • Hepatitis E / complications
  • Hepatitis E / diagnosis*
  • Hepatitis E / pathology
  • Hepatitis E / virology
  • Hepatitis E virus / classification
  • Hepatitis E virus / genetics*
  • Hepatitis E virus / isolation & purification
  • Humans
  • Immunocompetence
  • Male
  • Middle Aged
  • Phylogeny
  • RNA, Viral* / blood
  • RNA, Viral* / cerebrospinal fluid


  • RNA, Viral