Applications of Synthetic Organic Tetrasulfides as H2S Donors

Org Lett. 2017 May 5;19(9):2314-2317. doi: 10.1021/acs.orglett.7b00858. Epub 2017 Apr 25.


In an effort to expand the availability of simple polysulfides for H2S donation, we report here the synthesis and H2S release profiles of bis(aryl) and bis(alkyl) tetrasulfides. The tetrasulfide donors release H2S in a first-order dependence on reduced glutathione (GSH) and release more H2S than the commonly used trisulfide DATS.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.