Epigenetic modulators of thyroid cancer

Endocrinol Diabetes Nutr. 2017 Jan;64(1):44-56. doi: 10.1016/j.endinu.2016.09.006. Epub 2017 Jan 20.
[Article in English, Spanish]

Abstract

There are some well known factors involved in the etiology of thyroid cancer, including iodine deficiency, radiation exposure at early ages, or some genetic changes. However, epigenetic modulators that may contribute to development of these tumors and be helpful to for both their diagnosis and treatment have recently been discovered. The currently known changes in DNA methylation, histone modifications, and non-coding RNAs in each type of thyroid carcinoma are reviewed here.

Keywords: Carcinoma de tiroides; DNA methylation; Epigenetics; Epigenética; Histone modifications; Metilación de DNA; Modificación de histonas; Thyroid cancer; miRNA.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma, Follicular / genetics
  • Animals
  • Carcinoma, Medullary / genetics
  • Carcinoma, Papillary / genetics
  • Cell Transformation, Neoplastic / genetics*
  • Clinical Trials as Topic
  • CpG Islands / genetics
  • DNA Methylation
  • DNA, Neoplasm / genetics
  • Epigenesis, Genetic*
  • Histone Code
  • Histone Deacetylase Inhibitors / therapeutic use
  • Humans
  • Models, Genetic
  • Neoplasm Proteins / genetics
  • Oncogenes
  • Promoter Regions, Genetic / genetics
  • RNA, Neoplasm / genetics
  • RNA, Untranslated / genetics
  • Thyroid Neoplasms / drug therapy
  • Thyroid Neoplasms / genetics*

Substances

  • DNA, Neoplasm
  • Histone Deacetylase Inhibitors
  • Neoplasm Proteins
  • RNA, Neoplasm
  • RNA, Untranslated