Gut Microbiota: Small Molecules Modulate Host Cellular Functions

Curr Biol. 2017 Apr 24;27(8):R307-R310. doi: 10.1016/j.cub.2017.03.026.


The human gut metagenome was recently discovered to encode vast collections of biosynthetic gene clusters with diverse chemical potential, almost none of which are yet functionally validated. Recent work elucidates common microbiome-derived biosynthetic gene clusters encoding peptide aldehydes that inhibit human proteases.

Publication types

  • Comment

MeSH terms

  • Gastrointestinal Microbiome*
  • Humans
  • Metagenome
  • Microbiota*
  • Multigene Family
  • Peptide Hydrolases


  • Peptide Hydrolases