Background: Progesterone and adiponectin receptor family member 3 (PAQR3) is a recently discovered tumor suppressor gene, which affects the development of a tumor by inhibiting cell proliferation, cell malignant transformation, angiogenesis, and tumor metastasis. This study investigates the expression of PAQR3 in lung cancer and its clinical significance.
Methods: A total of 106 patients with lung cancer received surgical treatment in hospital, and adjacent normal tissues of these patients were utilized as control group. The diagnosis of all patients was confirmed through clinical pathology. The expression of PAQR3 protein was detected by immunohistochemistry in lung cancer and adjacent normal tissues. The clinical significance of its expression was also investigated.
Results: The positive expression rate of PAQR3 protein in lung cancer was lower than that in adjacent normal tissues (P<0.01). The positive expression rate of PAQR3 protein was unrelated to age, tumor size, and gender, but it exhibited a significant relationship with the pathological type and differentiation, TNM staging, and lymph node metastasis (P<0.05). Kaplan-Meier survival analysis showed that the five-year survival rate of patients with PAQR3 protein positive expression was higher than that in patients with negative expression (P=0.026).
Conclusions: The expression of PAQR3 protein significantly decreased in lung cancer, indicating that PAQR3 protein plays an important role in the pathogenesis of PAQR3 in lung cancer.
背景与目的 孕酮及脂联素受体家族成员3（progesterone and adiponectin receptor family member 3, PAQR3）是最新研究发现的抑癌基因，通过抑制细胞增殖、细胞恶性转化、抑制血管生成及肿瘤转移来影响肿瘤的发展。本研究旨在探讨PAQR3在肺癌组织中的表达及其临床意义。方法 选取天津医科大学总医院病理科2008年1月-2010年12月经病理明确诊断的106例肺癌组织标本作为实验组，同时取其癌旁正常组织作为对照。所有患者的诊断均经术后病理诊断证实，采用免疫组织化学方法检测PAQR3蛋白在肺癌组织和癌旁正常组织中的表达，并探讨其表达的临床意义。结果 PAQR3蛋白在肺癌组织中阳性表达率显著低于癌旁正常组织（P<0.01）；PAQR3蛋白的阳性表达率与患者的性别、年龄、肿瘤大小无关，与患者的病理分型、分化程度、TNM分期和有无淋巴结转移具有相关性（P<0.05）；Kaplan-Meier生存分析结果显示PAQR3蛋白阳性表达的患者5年生存率高于阴性表达的患者（P<0.05）。结论 PAQR3蛋白的表达量在肺癌组织中明显降低，提示PAQR3可能在肺癌的发病机制中发挥重要的作用。.