The antimicrobial peptide human beta-defensin 2 promotes itch through Toll-like receptor 4 signaling in mice

J Allergy Clin Immunol. 2017 Sep;140(3):885-888.e6. doi: 10.1016/j.jaci.2017.03.035. Epub 2017 Apr 23.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Infective Agents / pharmacology*
  • Ganglia, Spinal
  • HEK293 Cells
  • Humans
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Neurons / physiology
  • Pruritus / immunology*
  • Receptors, CCR2 / genetics
  • Receptors, CCR2 / immunology
  • Receptors, CCR6 / genetics
  • Receptors, CCR6 / immunology
  • Signal Transduction / drug effects
  • Skin / immunology
  • TRPV Cation Channels / genetics
  • Toll-Like Receptor 4 / genetics
  • Toll-Like Receptor 4 / immunology*
  • beta-Defensins / pharmacology*

Substances

  • Anti-Infective Agents
  • CCR6 protein, mouse
  • Ccr2 protein, mouse
  • DEFB4A protein, human
  • Receptors, CCR2
  • Receptors, CCR6
  • TRPV Cation Channels
  • TRPV1 protein, mouse
  • Tlr4 protein, mouse
  • Toll-Like Receptor 4
  • beta-Defensins