Antiinflammatory Activity of Cinnamon (Cinnamomum zeylanicum) Bark Essential Oil in a Human Skin Disease Model

Phytother Res. 2017 Jul;31(7):1034-1038. doi: 10.1002/ptr.5822. Epub 2017 Apr 26.

Abstract

The effect of cinnamon (Cinnamomum zeylanicum) bark essential oil (CBEO) on human skin cells has not been elucidated. Therefore, we investigated the activity of a commercially available CBEO in a validated human dermal fibroblast system, a model of chronic inflammation and fibrosis. We first evaluated the impact of CBEO on 17 protein biomarkers that play critical roles in inflammation and tissue remodeling. The impact of CBEO on genome-wide gene expression was also evaluated. CBEO showed strong anti-proliferative effects on skin cells and significantly inhibited the production of several inflammatory biomarkers, including vascular cell adhesion molecule-1, intercellular cell adhesion molecule-1, monocyte chemoattractant protein-1, interferon gamma-induced protein 10, interferon-inducible T-cell alpha chemoattractant, and monokine induced by gamma interferon. In addition, CBEO significantly inhibited the production of several tissue remodeling molecules, including epidermal growth factor receptor, matrix metalloproteinase-1, and plasminogen activator inhibitor-1. Macrophage colony-stimulating factor, which is an immunomodulatory protein molecule, was also significantly inhibited by CBEO. Furthermore, CBEO significantly modulated global gene expression and altered signaling pathways, many of which are important in inflammation, tissue remodeling, and cancer biology. The study shows that CBEO is a promising antiinflammatory agent; however, further research is required to clarify its clinical efficacy. © 2017 The Authors. Phytotherapy Research published by John Wiley & Sons Ltd.

Keywords: MIG; VCAM-1; cell proliferation; cinnamon bark essential oil; genome-wide gene expression; inflammation.

MeSH terms

  • Anti-Inflammatory Agents / pharmacology*
  • Cells, Cultured
  • Chemokine CCL2 / metabolism
  • Chemokine CXCL10 / metabolism
  • Cinnamomum zeylanicum / chemistry*
  • Fibroblasts / drug effects
  • Humans
  • Intercellular Adhesion Molecule-1 / metabolism
  • Macrophage Colony-Stimulating Factor / metabolism
  • Matrix Metalloproteinase 1 / metabolism
  • Oils, Volatile / pharmacology*
  • Phytotherapy
  • Plant Bark / chemistry
  • Plant Extracts / pharmacology*
  • Plasminogen Activator Inhibitor 1 / metabolism
  • Skin Diseases / drug therapy*
  • Vascular Cell Adhesion Molecule-1 / metabolism

Substances

  • Anti-Inflammatory Agents
  • CCL2 protein, human
  • CXCL10 protein, human
  • Chemokine CCL2
  • Chemokine CXCL10
  • Oils, Volatile
  • Plant Extracts
  • Plasminogen Activator Inhibitor 1
  • SERPINE1 protein, human
  • Vascular Cell Adhesion Molecule-1
  • Intercellular Adhesion Molecule-1
  • Macrophage Colony-Stimulating Factor
  • MMP1 protein, human
  • Matrix Metalloproteinase 1