Deoxygenation of Ethers To Form Carbon-Carbon Bonds via Nickel Catalysis

Zhi-Chao Cao; Zhang-Jie Shi

doi:10.1021/jacs.7b02326

Deoxygenation of Ethers To Form Carbon-Carbon Bonds via Nickel Catalysis

J Am Chem Soc. 2017 May 17;139(19):6546-6549. doi: 10.1021/jacs.7b02326. Epub 2017 May 3.

Authors

Zhi-Chao Cao¹, Zhang-Jie Shi^{1

2

3}

Affiliations

¹ College of Chemistry and Molecular Engineering, Peking University , Beijing 100871, China.
² Department of Chemistry, Fudan University , Shanghai 200433, China.
³ State Key Laboratory of Organometallic Chemistry, Chinese Academy of Science , Shanghai 200032, China.

PMID: 28445066
DOI: 10.1021/jacs.7b02326

Abstract

In this article a successful protocol was developed to construct carbon-carbon bonds by the extrusion of the O atom of ethers via nickel catalysis in the presence of reductants. This methodology is featured as a highly economic route to construct sp³-sp³ C-C bonds through dual C-O activation of ethers with good functional group tolerance.

Publication types

Research Support, Non-U.S. Gov't