NutrimiRAging: Micromanaging Nutrient Sensing Pathways through Nutrition to Promote Healthy Aging

Int J Mol Sci. 2017 Apr 26;18(5):915. doi: 10.3390/ijms18050915.


Current sociodemographic predictions point to a demographic shift in developed and developing countries that will result in an unprecedented increase of the elderly population. This will be accompanied by an increase in age-related conditions that will strongly impair human health and quality of life. For this reason, aging is a major concern worldwide. Healthy aging depends on a combination of individual genetic factors and external environmental factors. Diet has been proved to be a powerful tool to modulate aging and caloric restriction has emerged as a valuable intervention in this regard. However, many questions about how a controlled caloric restriction intervention affects aging-related processes are still unanswered. Nutrient sensing pathways become deregulated with age and lose effectiveness with age. These pathways are a link between diet and aging. Thus, fully understanding this link is a mandatory step before bringing caloric restriction into practice. MicroRNAs have emerged as important regulators of cellular functions and can be modified by diet. Some microRNAs target genes encoding proteins and enzymes belonging to the nutrient sensing pathways and, therefore, may play key roles in the modulation of the aging process. In this review, we aimed to show the relationship between diet, nutrient sensing pathways and microRNAs in the context of aging.

Keywords: Mediterranean diet; caloric restriction; cardiovascular disease; circulating microRNAs; dietary restriction; healthy aging; intermittent fasting; lifespan; microRNAs; type 2 diabetes.

Publication types

  • Review

MeSH terms

  • Animals
  • Caloric Restriction
  • Healthy Aging / genetics*
  • Humans
  • Longevity
  • MicroRNAs / blood
  • MicroRNAs / metabolism*
  • Nutritional Status
  • RNA, Untranslated / metabolism
  • Signal Transduction / genetics


  • MicroRNAs
  • RNA, Untranslated