Signaling by Antibodies: Recent Progress

Annu Rev Immunol. 2017 Apr 26:35:285-311. doi: 10.1146/annurev-immunol-051116-052433.


IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed, balanced IgG signaling through type I and type II Fc receptors is required for the control of proinflammatory, anti-inflammatory, and immunomodulatory processes. In this review, we discuss the mechanisms that govern IgG-Fc receptor interactions, highlighting the diversity of Fc receptor-mediated effector functions that regulate immunity and inflammation as well as determine susceptibility to infection and autoimmunity and responsiveness to antibody-based therapeutics and vaccines.

Keywords: Fc receptors; IgG; effector function; immunity; immunomodulation; inflammation.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies / therapeutic use*
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / therapy
  • Disease Susceptibility
  • Humans
  • Immunity, Humoral
  • Immunoglobulin G / metabolism*
  • Immunotherapy / methods*
  • Infections / immunology*
  • Infections / therapy
  • Inflammation
  • Receptors, Fc / metabolism*
  • Signal Transduction


  • Antibodies
  • Immunoglobulin G
  • Receptors, Fc