Opioid substitution treatment is linked to reduced risk of death in opioid use disorder

doi:10.1136/bmj.j1947

Editorial

. 2017 Apr 26:357:j1947.

doi: 10.1136/bmj.j1947.

Opioid substitution treatment is linked to reduced risk of death in opioid use disorder

Ajay Manhapra^{1

2}, Robert Rosenheck², David A Fiellin²

Affiliations

PMID: 28446438
PMCID: PMC5412085
DOI: 10.1136/bmj.j1947

Editorial

Opioid substitution treatment is linked to reduced risk of death in opioid use disorder

Ajay Manhapra et al. BMJ. 2017.

. 2017 Apr 26:357:j1947.

doi: 10.1136/bmj.j1947.

Authors

Ajay Manhapra^{1

2}, Robert Rosenheck², David A Fiellin²

Affiliations

¹ VA Hampton Medical Center, Hampton, VA, USA.
² Yale School of Medicine, New Haven, CT, USA.

PMID: 28446438
PMCID: PMC5412085
DOI: 10.1136/bmj.j1947

Abstract

Sustained engagement in treatment is vital, particularly in the first “golden month”

PubMed Disclaimer

Conflict of interest statement

Competing interests: We have read and understood the BMJ Group policy on declaration of interests and declare that DF has advised a consultancy firm on the risk of diversion and misuse of buprenorphine

Comment on

Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies.
Sordo L, Barrio G, Bravo MJ, Indave BI, Degenhardt L, Wiessing L, Ferri M, Pastor-Barriuso R. Sordo L, et al. BMJ. 2017 Apr 26;357:j1550. doi: 10.1136/bmj.j1550. BMJ. 2017. PMID: 28446428 Free PMC article. Review.

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Rationale, design and methods of VA-BRAVE: a randomized comparative effectiveness trial of two formulations of buprenorphine for treatment of opioid use disorder in veterans.
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Seval N, Frank CA, Litwin AH, Roth P, Schade MA, Pavlicova M, Levin FR, Brady KT, Nunes EV, Springer SA. Seval N, et al. Contemp Clin Trials. 2021 Jun;105:106394. doi: 10.1016/j.cct.2021.106394. Epub 2021 Apr 7. Contemp Clin Trials. 2021. PMID: 33838307 Free PMC article. Clinical Trial.
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References

1. Rudd RA, Seth P, David F, Scholl L. Increases in Drug and Opioid-Involved Overdose Deaths - United States, 2010-2015. MMWR Morb Mortal Wkly Rep 2016;65:1445-52. 10.15585/mmwr.mm655051e1 pmid:28033313. - DOI - PubMed
1. Samet JH, Fiellin DA. Opioid substitution therapy-time to replace the term. Lancet 2015;385:1508-9. 10.1016/S0140-6736(15)60750-4 pmid:25933278. - DOI - PubMed
1. Presidential Memorandum -- Addressing Prescription Drug Abuse and Heroin Use. 2015. https://obamawhitehouse.archives.gov/the-press-office/2015/10/21/preside...
1. Sordo L, Barrio G, Bravo MJ, et al. Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies. BMJ 2017;357:j1550. - PMC - PubMed
1. Grella CE, Stein JA. Remission from substance dependence: differences between individuals in a general population longitudinal survey who do and do not seek help. Drug Alcohol Depend 2013;133:146-53. 10.1016/j.drugalcdep.2013.05.019 pmid:23791039. - DOI - PMC - PubMed

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[1] Rudd RA, Seth P, David F, Scholl L. Increases in Drug and Opioid-Involved Overdose Deaths - United States, 2010-2015. MMWR Morb Mortal Wkly Rep 2016;65:1445-52. 10.15585/mmwr.mm655051e1 pmid:28033313. - DOI - PubMed

[2] Rudd RA, Seth P, David F, Scholl L. Increases in Drug and Opioid-Involved Overdose Deaths - United States, 2010-2015. MMWR Morb Mortal Wkly Rep 2016;65:1445-52. 10.15585/mmwr.mm655051e1 pmid:28033313. - DOI - PubMed

[3] Samet JH, Fiellin DA. Opioid substitution therapy-time to replace the term. Lancet 2015;385:1508-9. 10.1016/S0140-6736(15)60750-4 pmid:25933278. - DOI - PubMed

[4] Samet JH, Fiellin DA. Opioid substitution therapy-time to replace the term. Lancet 2015;385:1508-9. 10.1016/S0140-6736(15)60750-4 pmid:25933278. - DOI - PubMed

[5] Presidential Memorandum -- Addressing Prescription Drug Abuse and Heroin Use. 2015. https://obamawhitehouse.archives.gov/the-press-office/2015/10/21/preside...

[6] Presidential Memorandum -- Addressing Prescription Drug Abuse and Heroin Use. 2015. https://obamawhitehouse.archives.gov/the-press-office/2015/10/21/preside...

[7] Sordo L, Barrio G, Bravo MJ, et al. Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies. BMJ 2017;357:j1550. - PMC - PubMed

[8] Sordo L, Barrio G, Bravo MJ, et al. Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies. BMJ 2017;357:j1550. - PMC - PubMed

[9] Grella CE, Stein JA. Remission from substance dependence: differences between individuals in a general population longitudinal survey who do and do not seek help. Drug Alcohol Depend 2013;133:146-53. 10.1016/j.drugalcdep.2013.05.019 pmid:23791039. - DOI - PMC - PubMed

[10] Grella CE, Stein JA. Remission from substance dependence: differences between individuals in a general population longitudinal survey who do and do not seek help. Drug Alcohol Depend 2013;133:146-53. 10.1016/j.drugalcdep.2013.05.019 pmid:23791039. - DOI - PMC - PubMed

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Opioid substitution treatment is linked to reduced risk of death in opioid use disorder

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Opioid substitution treatment is linked to reduced risk of death in opioid use disorder

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