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. 2017 Apr 27;19(5):410-412.
doi: 10.1038/ncb3519.

Terminating the Replication Helicase


Terminating the Replication Helicase

Vincent Gaggioli et al. Nat Cell Biol. .


A feature of the cell cycle is that the events of one cycle must be reset before the next one begins. A study now shows that the replication machinery is removed from fully replicated DNA by a conserved ubiquitin- and CDC48 (also known as p97)-dependent pathway. This explains how eukaryotic chromosomes are returned to the unreplicated state.

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