No relation between biomarkers at age 47-49 and aortic diameter after 14-19 years of follow-up - a population-based study

Vasa. 2017 Jul;46(4):291-295. doi: 10.1024/0301-1526/a000632. Epub 2017 Apr 27.


Background: Biomarkers reflecting diverse pathophysiological pathways may play an important role in the pathogenesis of abdominal aortic aneurysm (aortic diameter ≥30 mm, AAA), levels of many biomarkers are elevated and correlated to aortic diameter among 65-year-old men undergoing ultrasound (US) screening for AAA.

Probands and methods: To evaluate potential relationships between biomarkers and aortic dilatation after long-term follow-up, levels of C-reactive protein (CRP), proneurotensin (PNT), copeptin (CPT), lipoprotein-associated phospholipase 2 (Lp-PLA2), cystatin C (Cyst C), midregional proatrial natriuretic peptide (MR-proANP), and midregional proadrenomedullin (MR-proADM) were measured in 117 subjects (114 [97 %] men) aged 47-49 in a prospective population-based cohort study, and related to aortic diameter at US examination of the aorta after 14-19 years of follow-up.

Results: Biomarker levels at baseline did not correlate with aortic diameter after 14-19 years of follow up (CRP [r = 0.153], PNT [r = 0.070], CPT [r = -.156], Lp-PLA2 [r = .024], Cyst C [r = -.015], MR-proANP [r = 0.014], MR-proADM [r = -.117]). Adjusting for age and smoking at baseline in a linear regression model did not reveal any significant correlations.

Conclusions: Tested biomarker levels at age 47-49 were not associated with aortic diameter at ultrasound examination after 14-19 years of follow-up. If there are relationships between these biomarkers and aortic dilatation, they are not relevant until closer to AAA diagnosis.

Keywords: Biomarkers; aortic aneurysm; aortic diameter.

MeSH terms

  • Age Factors
  • Aged
  • Aorta, Abdominal / diagnostic imaging*
  • Aorta, Abdominal / pathology
  • Aortic Aneurysm, Abdominal / blood*
  • Aortic Aneurysm, Abdominal / diagnostic imaging*
  • Aortic Aneurysm, Abdominal / pathology
  • Biomarkers / blood
  • Dilatation, Pathologic
  • Disease Progression
  • Follow-Up Studies
  • Humans
  • Inflammation Mediators / blood*
  • Linear Models
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prospective Studies
  • Risk Factors
  • Smoking / adverse effects
  • Time Factors
  • Ultrasonography*


  • Biomarkers
  • Inflammation Mediators