A case of diffuse Lewy body and Alzheimer's diseases with periodic synchronous discharges

J Neuropathol Exp Neurol. 1988 Sep;47(5):536-48. doi: 10.1097/00005072-198809000-00005.


Periodic synchronous discharges were consistently observed in a 68-year-old man with a four-year history of progressive dementia. Pathological examination revealed diffuse atrophy of the brain with remarkable dilatation of the temporal horns. Histologically there were severe changes of Alzheimer's disease and diffuse Lewy bodies (LB), either typical or less distinctive ones without clear halos. Cerebellar LB were also observed in the cerebellum. Four types of abnormal intraneuronal filamentous structures were observed: neurofibrillary tangles, accumulated neurofilaments, thick linear structures studded with ribosome-like dense granules, and fuzzy, thin filaments similar to, but generally wider than, a neurofilament.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / pathology*
  • Alzheimer Disease / physiopathology
  • Brain / pathology*
  • Brain / physiopathology
  • Brain / ultrastructure
  • Choline O-Acetyltransferase / metabolism
  • Creutzfeldt-Jakob Syndrome / pathology
  • Creutzfeldt-Jakob Syndrome / physiopathology
  • Electroencephalography
  • Humans
  • Inclusion Bodies / ultrastructure
  • Intermediate Filaments / ultrastructure
  • Male
  • Microscopy, Electron
  • Middle Aged
  • Neurofibrils / ultrastructure
  • Reference Values


  • Choline O-Acetyltransferase