The structure of a plasmid of Chlamydia trachomatis believed to be required for growth within mammalian cells

Mol Microbiol. 1988 Jul;2(4):531-8. doi: 10.1111/j.1365-2958.1988.tb00060.x.


Sequence analysis of a 7.5 kb DNA plasmid isolated from Chlamydia trachomatis shows 8 open reading frames (ORFs) regularly spaced along most of the sequence. One of these ORFs encodes a 451-amino-acid polypeptide highly homologous to the DnaB protein of Escherichia coli. A region between ORFs 6 and 7 contains a cluster of alternating ATs and a 22 bp sequence tandemly repeated 4 times, suggesting a replication control region. Several ORFs correspond to plasmid-specific polypeptides that have been described. Codons ending with A or T are more frequent, as might be expected from the high A/T content (64%) of the plasmid, and codon usage is similar to that of the C. trachomatis chromosomal gene, omp1L2.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Chlamydia trachomatis / genetics*
  • Chlamydia trachomatis / growth & development
  • Cloning, Molecular
  • Codon
  • DNA Restriction Enzymes
  • DNA, Bacterial*
  • Molecular Sequence Data
  • Plasmids*


  • Codon
  • DNA, Bacterial
  • DNA Restriction Enzymes

Associated data

  • GENBANK/X07547