Rapid diagnostic test for ocular adenovirus

Ophthalmology. 1988 Apr;95(4):431-3. doi: 10.1016/s0161-6420(88)33168-4.


A new, direct, enzyme immunoassay test (Adenoclone, Cambridge BioScience, Hopkinton, MA) was evaluated for the rapid diagnosis of ocular adenovirus infections. In 36 culture-proven cases of adenovirus ocular infection, direct Adenoclone testing of conjunctival swabs was positive in 24 of 31 patients (77%) tested within 1 week of onset of symptoms, and in one of five patients (20%) who presented after 1 week (P less than 0.02). Overall sensitivity was 69%, whereas specificity was 100%. The authors conclude that a positive Adenoclone test is reliable in the rapid diagnosis of early adenovirus ocular infections.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenoviridae Infections / diagnosis*
  • Adenovirus Infections, Human / diagnosis*
  • Evaluation Studies as Topic
  • Eye Diseases / diagnosis*
  • Humans
  • Reagent Kits, Diagnostic / standards
  • Retrospective Studies
  • Time Factors


  • Reagent Kits, Diagnostic