Codon usage in Pseudomonas aeruginosa

Nucleic Acids Res. 1988 Oct 11;16(19):9323-35. doi: 10.1093/nar/16.19.9323.


We have generated a codon usage table for Pseudomonas aeruginosa. Codon usage in P. aeruginosa is extremely biased. In contrast to E. coli and yeast, P. aeruginosa preferentially uses those codons within a synonymous codon group with the strongest predicted codon-anticodon interaction. We were unable to correlate a particular codon usage pattern with predicted levels of mRNA expressivity. The choice of a third base reflects the high guanine plus cytosine content of the P. aeruginosa genome (67.2%) and cytosine is the preferred nucleotide for the third codon position.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Bacteriophages / genetics
  • Chromosomes, Bacterial
  • Codon*
  • DNA Transposable Elements
  • Gene Expression Regulation
  • Genes
  • Genes, Bacterial
  • Plasmids
  • Pseudomonas aeruginosa / genetics*
  • RNA, Messenger* / genetics


  • Codon
  • DNA Transposable Elements
  • RNA, Messenger