Simultaneous Recordings of Central and Peripheral Bioelectrical Signals in a Freely Moving Rodent

Biol Pharm Bull. 2017;40(5):711-715. doi: 10.1248/bpb.b17-00070.


Understanding physiological interactions between the central and peripheral nervous systems requires an experimental strategy to simultaneously monitor activity patterns of the brain and peripheral organs. In this study, we developed a novel method to record extracellular field potential signals from a wide range of brain regions together with electrocardiograms, electromyograms, and breathing signals from a freely moving rodent. This method collects all recorded signals into a single device mounted on an animal's head, allowing the reduction of experimental costs and the simplification of data processing. The methodological concept is applicable to a number of biological research issues of how the brain-body association is altered in response to various environmental changes, emotional challenges, and acute and chronic dysfunction of internal organs.

Keywords: breathing; electromyogram; heart rate; local field potential.

MeSH terms

  • Animals
  • Behavior, Animal / physiology
  • Central Nervous System / physiology*
  • Electrocardiography
  • Electrodes, Implanted
  • Electromyography
  • Electrophysiological Phenomena
  • Electrophysiology / instrumentation
  • Electrophysiology / methods*
  • Emotions
  • Extracellular Space / physiology
  • Male
  • Peripheral Nervous System / physiology*
  • Rats
  • Rats, Wistar
  • Respiration