Co-administration of creatine and guanidinoacetic acid for augmented tissue bioenergetics: A novel approach?

Sergej M Ostojic

doi:10.1016/j.biopha.2017.04.075

Co-administration of creatine and guanidinoacetic acid for augmented tissue bioenergetics: A novel approach?

Biomed Pharmacother. 2017 Jul:91:238-240. doi: 10.1016/j.biopha.2017.04.075. Epub 2017 Apr 28.

Author

Sergej M Ostojic¹

Affiliation

¹ Faculty of Sport and PE, University of Novi Sad, Novi Sad, Serbia; University of Belgrade School of Medicine, Belgrade, Serbia. Electronic address: sergej.ostojic@chess.edu.rs.

PMID: 28460226
DOI: 10.1016/j.biopha.2017.04.075

Abstract

A confined absorption of exogenous creatine through creatine transporter (CRT1) seems to hamper its optimal uptake in bioenergetical deficits. Co-administration of guanidinoacetic acid (GAA) along with creatine could target other transport channels besides CRT1, and supremely improve cellular levels of creatine. This innovative approach might tackle tissues difficult to reach with conventional creatine interventions, providing a potentially more effective and safe mixture in clinical pharmacology and therapeutics.

Keywords: Creatine transporter; GAT2; Guanidinoacetic acid; SLC6A6.

MeSH terms

Creatine / administration & dosage*
Creatine / pharmacology*
Energy Metabolism*
Glycine / administration & dosage
Glycine / analogs & derivatives*
Glycine / pharmacology
Models, Biological
Organ Specificity*

Substances

glycocyamine
Creatine
Glycine