NDM-5 and OXA-181 Beta-Lactamases, a Significant Threat Continues To Spread in the Americas

Antimicrob Agents Chemother. 2017 Jun 27;61(7):e00454-17. doi: 10.1128/AAC.00454-17. Print 2017 Jul.


Among Gram-negative bacteria, carbapenem-resistant infections pose a serious and life-threatening challenge. Here, the CRACKLE network reports a sentinel detection and characterization of a carbapenem-resistant Klebsiella pneumoniae ST147 isolate harboring blaNDM-5 and blaOXA-181 from a young man who underwent abdominal surgery in India. blaNDM-5 was located on an IncFII plasmid of ≈90 kb, whereas blaOXA-181 was chromosomally encoded. Resistome and genome analysis demonstrated multiple copies of the transposable element IS26 and a "hot-spot region" in the IncFII plasmid.

Keywords: Klebsiella pneumoniae; NDM-5; OXA-181.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use
  • Carbapenems / pharmacology
  • Carbapenems / therapeutic use
  • Humans
  • India
  • Klebsiella Infections / drug therapy
  • Klebsiella Infections / microbiology
  • Klebsiella pneumoniae / enzymology*
  • Klebsiella pneumoniae / pathogenicity*
  • Male
  • Microbial Sensitivity Tests
  • Plasmids / genetics
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism*


  • Anti-Bacterial Agents
  • Carbapenems
  • beta-Lactamases