Depression and chronic pain in the elderly: links and management challenges

Clin Interv Aging. 2017 Apr 21:12:709-720. doi: 10.2147/CIA.S113576. eCollection 2017.

Abstract

Aging is an inevitable process and represents the accumulation of bodily alterations over time. Depression and chronic pain are highly prevalent in elderly populations. It is estimated that 13% of the elderly population will suffer simultaneously from the two conditions. Accumulating evidence suggests than neuroinflammation plays a critical role in the pathogenesis of both depression and chronic pain. Apart from the common pathophysiological mechanisms, however, the two entities have several clinical links. Their management is challenging for the pain physician; however, both pharmacologic and nonpharmacologic approaches are available and can be used when the two conditions are comorbid in the elderly patients.

Keywords: chronic pain; cognitive impairment; depression; elderly; neuroinflammation; pain.

Publication types

  • Review

MeSH terms

  • Aged
  • Aging*
  • Chronic Pain / epidemiology*
  • Comorbidity
  • Depression / epidemiology*
  • Depressive Disorder / epidemiology
  • Humans
  • Pain Management