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. 2018 Feb;20(2):182-187.
doi: 10.1080/10286020.2017.1322070. Epub 2017 May 2.

Cytotoxic Triterpenes From the Acid Hydrolyzate of Gynostemma Pentaphyllum Saponins

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Cytotoxic Triterpenes From the Acid Hydrolyzate of Gynostemma Pentaphyllum Saponins

Lin Shi et al. J Asian Nat Prod Res. .

Abstract

One new dammarane-type triterpene, gypsapogenin A (1), was isolated from the acid hydrolyzate of total saponins from Gynostemma pentaphyllum (Thunb.) Makino, together with two known compounds, (20S,24S)-3β,20,21β,23β,25-pentahydroxy-21,24-cyclodammarane (2) and (23S)-3β-hydroxydammar-20,24-dien-21-oic acid 21,23-lactone (3). Its structural elucidations were accomplished mainly on the basis of the interpretation of spectroscopic data, such as IR, HR-TOF-MS, and NMR. The cytotoxic activities were evaluated against HepG2 and A549 human cancer cell lines.

Keywords: Gynostemma pentaphyllum; antitumor; hydrolyzate; triterpene.

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