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Clinical Trial
. 2017 Sep;49(7):640-644.
doi: 10.1002/lsm.22674. Epub 2017 May 2.

Multiple Same Day Cryolipolysis Treatments for the Reduction of Subcutaneous Fat Are Safe and Do Not Affect Serum Lipid Levels or Liver Function Tests

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Free PMC article
Clinical Trial

Multiple Same Day Cryolipolysis Treatments for the Reduction of Subcutaneous Fat Are Safe and Do Not Affect Serum Lipid Levels or Liver Function Tests

Kenneth B Klein et al. Lasers Surg Med. .
Free PMC article

Abstract

Objective: Cryolipolysis is a safe and effective non-surgical procedure for reducing subcutaneous fat. It spares adjacent structures, is associated with few adverse events, and is well-tolerated by patients. Previous studies involving one or two simultaneous treatment sites have shown no effect on serum lipid levels or liver tests. The purpose of this study was to determine whether multiple same day treatments (abdomen plus both flanks) result in changes in these blood tests, and is safe.

Study design: Thirty-five adult males and females underwent same-day cryolipolysis (CoolSculpting System, ZELTIQ Aesthetics) of the lower abdomen and flanks for reduction of subcutaneous fat. Serum lipids and liver tests were measured prior to treatment and at 1, 4, and 12 weeks post-treatment. Expected treatment side-effects were assessed immediately post-treatment and at the 12-week follow-up visit. Adverse events were also monitored.

Methods: Treatment consisted of one cycle to the lower abdomen using a large vacuum applicator and simultaneous treatment of both flanks, one cycle each, with medium vacuum applicators .Time between the abdomen and flanks procedures was not to exceed 30 minutes.

Results: The procedures were well-tolerated by patients; expected treatment effects were in general mild or moderate, and resolved without intervention. There were no clinically meaningful changes from baseline to any subsequent time point in any serum lipid test. This was also true for all liver tests. There were no treatment-related adverse events.

Conclusion: Multiple cycle, same day cryolipolysis treatment of the lower abdomen and both flanks is well-tolerated and safe. It does not lead to changes in serum lipids or liver tests at any of the measured time points following the procedure. Lasers Surg. Med. 49:640-644, 2017. © 2017 The Authors. Lasers in Surgery and Medicine Published by Wiley Periodicals Inc.

Keywords: liver tests; non-invasive body contouring; non-surgical fat reduction; serum lipids.

Figures

Figure 1
Figure 1
Plot of mean cholesterol values reveals no significant change over time. Further, mean values ± their 95% confidence interval (denoted by the error bars) remain near the reference range (shown as dashed lines).
Figure 2
Figure 2
Plot of mean triglyceride values reveals no clinically meaningful change over time. Further, mean values ± their 95% confidence interval (denoted by the error bars) remain well below the upper limit of the reference range (shown as a dashed line).
Figure 3
Figure 3
Plot of mean AST values reveals no significant change over time. Further, mean values ± their 95% confidence interval (denoted by the error bars) remain well within the reference range (shown as dashed lines).
Figure 4
Figure 4
Plot of mean ALT values reveals no significant change over time. Further, mean values ± their 95% confidence interval (denoted by the error bars) remain well within the reference range (shown as dashed lines).

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References

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