Polymorphonuclear leucocyte dysfunction during short term metabolic changes from normo- to hyperglycemia in type 1 (insulin dependent) diabetic patients

Infection. Jul-Aug 1988;16(4):215-21. doi: 10.1007/BF01650754.


Polymorphonuclear leucocyte (PMN) ingestion of particles coated with lipopolysaccharide (LPS) from Escherichia coli was compared to other PMN functions in seven patients with insulin dependent diabetes mellitus (IDDM) during short-term controlled metabolic changes from normo- to hyperglycemia without ketoacidosis. Factors known to interfere with PMN functions were excluded. PMN ingestion of particles coated with both LPS and bovine serum albumin became reduced from normo- to hyperglycemia. PMN motility was impaired in IDDM, but did not seem to be affected by short-term changes in metabolic control. PMN metabolism did not change from normo-to hyperglycemia. Particle-uptake by diabetic PMN is impaired after short term hyperglycemia in the range normally occurring in diabetics in every-day life.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Bactericidal Activity
  • Blood Glucose / metabolism
  • Chemotaxis, Leukocyte
  • Diabetes Mellitus, Type 1 / immunology*
  • Diabetes Mellitus, Type 1 / metabolism
  • Escherichia coli
  • Humans
  • Hyperglycemia / immunology*
  • Hyperglycemia / metabolism
  • Lipopolysaccharides
  • Male
  • Neutrophils / immunology
  • Neutrophils / metabolism
  • Neutrophils / physiology*
  • Phagocytosis
  • Superoxides / metabolism


  • Blood Glucose
  • Lipopolysaccharides
  • Superoxides