Sclerosing stromal tumor of the ovary. A light, electron microscopic and enzyme histochemical study

Int J Gynecol Pathol. 1988;7(3):280-90. doi: 10.1097/00004347-198809000-00008.


A sclerosing stromal ovarian tumor from a 15-year-old girl was studied. Enzyme histochemistry demonstrated the presence of 17 beta-estradiol, secondary alcohol, glucose-6-phosphate, and isocitrate dehydrogenase activities, strongly implicating that the tumor had steroidogenic capability. Electron microscopy revealed a diverse cellular population composed of conspicuous lipid-laden cells, fibroblast-like and undifferentiated primitive mesenchymal cells. The findings of the latter cell type and intermediate forms confirmed the stromal origin of sclerosing stromal tumor of the ovary.

Publication types

  • Case Reports

MeSH terms

  • 17-Hydroxysteroid Dehydrogenases / analysis
  • Adolescent
  • Alcohol Dehydrogenase / analysis
  • Female
  • Glucose-6-Phosphate
  • Glucosephosphates / analysis
  • Histocytochemistry
  • Humans
  • Isocitrate Dehydrogenase / analysis
  • Microscopy, Electron
  • Ovarian Neoplasms* / enzymology
  • Ovarian Neoplasms* / ultrastructure
  • Sclerosis


  • Glucosephosphates
  • Glucose-6-Phosphate
  • 17-Hydroxysteroid Dehydrogenases
  • Alcohol Dehydrogenase
  • 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))
  • Isocitrate Dehydrogenase
  • 3 (or 17)-beta-hydroxysteroid dehydrogenase