A repeat sequence, GGGTTA, is shared by DNA of human herpesvirus 6 and Marek's disease virus

J Virol. 1988 Dec;62(12):4824-7. doi: 10.1128/JVI.62.12.4824-4827.1988.

Abstract

Some regions of the genomes of human B-lymphotrophic virus (HBLV), also designated as human herpesvirus 6, and Marek's disease virus were found to hybridize to each other under moderate to stringent conditions, scoring from 10 to 30% base-pair mismatch. Nucleotide sequence analysis showed that a 6-base-pair repetitive sequence, GGGTTA (DR2), present in the IRS-IRL junction region of the Marek's disease virus genome, was also reiterated in the HBLV genome. The function(s) of such a sequence is unknown, but this is the first report of homology between HBLV and a nonhuman herpesvirus.

MeSH terms

  • Animals
  • Base Sequence
  • Blotting, Southern
  • Cross Reactions
  • DNA Probes
  • DNA Restriction Enzymes
  • DNA, Viral / genetics*
  • Deoxyribonuclease BamHI
  • Herpesviridae / genetics*
  • Herpesvirus 2, Gallid / genetics*
  • Humans
  • Nucleic Acid Hybridization
  • Repetitive Sequences, Nucleic Acid*

Substances

  • DNA Probes
  • DNA, Viral
  • DNA Restriction Enzymes
  • Deoxyribonuclease BamHI