Effects of magnesium on calcium phosphate formation

Magnesium. 1988;7(3):123-32.

Abstract

All biological calcium phosphates form in various neutral aqueous solutions containing [CaCl2] = 1 or 3 mM, [MgCl2] = 0-9 mM, [Na2HPO4] = 0.1-90 mM and NaCl (total 300 mosM) kept quiescently at 37 degrees C for 21 days. In all solutions containing 1 mM Ca and in solutions with [Ca] = 3 mM and [PO4] less than 10 mM, heterogeneous nucleation of octa-calcium phosphate (for Mg/Ca less than or equal to 1) or brushite (for Mg/Ca greater than 1) was observed; the former transforming to apatite with time. In contrast, homogeneous nucleation of an unstable amorphous calcium magnesium phosphate occurred in solutions with [Ca] = 3 mM and [PO4] greater than or equal to 10 mM, transforming to apatite, to brushite, and to whitlockite (and newberyite) depending on Mg/Ca and [PO4] values.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Apatites
  • Calcium Phosphates*
  • Chemical Precipitation
  • Crystallization
  • Durapatite
  • Hydrogen-Ion Concentration
  • Hydroxyapatites
  • Magnesium / pharmacology*
  • Magnesium Compounds*
  • Phosphates
  • Solutions
  • X-Ray Diffraction

Substances

  • Apatites
  • Calcium Phosphates
  • Hydroxyapatites
  • Magnesium Compounds
  • Phosphates
  • Solutions
  • alpha-tricalcium phosphate
  • tetracalcium phosphate
  • octacalcium phosphate
  • whitlockite
  • calcium magnesium phosphate
  • magnesium phosphate
  • calcium phosphate, monobasic, anhydrous
  • Durapatite
  • calcium phosphate
  • Magnesium
  • calcium phosphate, dibasic, anhydrous
  • calcium phosphate, dibasic, dihydrate