The Evolution of Organellar Coat Complexes and Organization of the Eukaryotic Cell

Annu Rev Biochem. 2017 Jun 20;86:637-657. doi: 10.1146/annurev-biochem-061516-044643. Epub 2017 May 3.

Abstract

Eukaryotic cells possess a remarkably diverse range of organelles that provide compartmentalization for distinct cellular functions and are likely responsible for the remarkable success of these organisms. The origins and subsequent elaboration of these compartments represent a key aspect in the transition between prokaryotic and eukaryotic cellular forms. The protein machinery required to build, maintain, and define many membrane-bound compartments is encoded by several paralog families, including small GTPases, coiled-bundle proteins, and proteins with β-propeller and α-solenoid secondary structures. Together these proteins provide the membrane coats and control systems to structure and coordinate the endomembrane system. Mechanistically and evolutionarily, they unite not only secretory and endocytic organelles but also the flagellum and nucleus. The ancient origins for these families have been revealed by recent findings, providing new perspectives on the deep evolutionary processes and relationships that underlie eukaryotic cell structure.

Keywords: clathrin; coated vesicle; coatomer; eukaryogenesis; intraflagellar transport; membrane trafficking; molecular evolution; nuclear pore complex; nucleocytoplasmic transport; protocoatomer.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Active Transport, Cell Nucleus
  • Cell Membrane / chemistry
  • Cell Membrane / metabolism
  • Cell Membrane / ultrastructure*
  • Clathrin / chemistry*
  • Clathrin / genetics
  • Clathrin / metabolism
  • Coat Protein Complex I / chemistry*
  • Coat Protein Complex I / genetics
  • Coat Protein Complex I / metabolism
  • Coated Vesicles / chemistry
  • Coated Vesicles / metabolism
  • Coated Vesicles / ultrastructure*
  • Eukaryotic Cells / chemistry
  • Eukaryotic Cells / metabolism
  • Eukaryotic Cells / ultrastructure*
  • Evolution, Molecular
  • Flagella / chemistry
  • Flagella / metabolism
  • Flagella / ultrastructure
  • Gene Expression
  • Models, Molecular
  • Monomeric GTP-Binding Proteins / chemistry*
  • Monomeric GTP-Binding Proteins / genetics
  • Monomeric GTP-Binding Proteins / metabolism
  • Nuclear Pore / chemistry
  • Nuclear Pore / metabolism
  • Nuclear Pore / ultrastructure
  • Protein Conformation, alpha-Helical
  • Protein Conformation, beta-Strand
  • Protein Domains

Substances

  • Clathrin
  • Coat Protein Complex I
  • Monomeric GTP-Binding Proteins