The Growth Differentiation Factor 11 (GDF11) and Myostatin (MSTN) in tissue specific aging

Xiaolan Fan; Uma Gaur; Lin Sun; Deying Yang; Mingyao Yang

doi:10.1016/j.mad.2017.04.009

The Growth Differentiation Factor 11 (GDF11) and Myostatin (MSTN) in tissue specific aging

Mech Ageing Dev. 2017 Jun;164:108-112. doi: 10.1016/j.mad.2017.04.009. Epub 2017 May 1.

Authors

Xiaolan Fan¹, Uma Gaur¹, Lin Sun², Deying Yang¹, Mingyao Yang³

Affiliations

¹ Institute of Animal Genetics and Breeding, Sichuan Agricultural University Chengdu, 611130, PR China.
² Jiangsu Vocational College of Medicine, Yancheng, 224000, PR China.
³ Institute of Animal Genetics and Breeding, Sichuan Agricultural University Chengdu, 611130, PR China. Electronic address: yangmingyao@sicau.edu.cn.

PMID: 28472635
DOI: 10.1016/j.mad.2017.04.009

Abstract

Growth differentiation factor 11 (GDF11) and myostatin (MSTN) are evolutionarily conserved homologues proteins which are closely related members of the transforming growth factor β superfamily. They are often perceived to serve similar or overlapping roles. Recently, GDF11 has been identified as playing a role during aging, however there are conflicting reports as to the nature of this role. In this review, we will discuss the literature regarding functions of GDF11 and myostatin in the heart, brain, and skeletal muscle during aging. Consequently we expect to develop a deeper understanding about the function of these two proteins in organismal aging and disease.

Keywords: Aging; GDF11; MSTN; Organismal aging.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Aging / metabolism*
Animals
Bone Morphogenetic Proteins / metabolism*
Growth Differentiation Factors / metabolism*
Humans
Myostatin / metabolism*
Organ Specificity

Substances

Bone Morphogenetic Proteins
GDF11 protein, human
Growth Differentiation Factors
MSTN protein, human
Myostatin