Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jun;164:108-112.
doi: 10.1016/j.mad.2017.04.009. Epub 2017 May 1.

The Growth Differentiation Factor 11 (GDF11) and Myostatin (MSTN) in Tissue Specific Aging

Affiliations
Review

The Growth Differentiation Factor 11 (GDF11) and Myostatin (MSTN) in Tissue Specific Aging

Xiaolan Fan et al. Mech Ageing Dev. .

Abstract

Growth differentiation factor 11 (GDF11) and myostatin (MSTN) are evolutionarily conserved homologues proteins which are closely related members of the transforming growth factor β superfamily. They are often perceived to serve similar or overlapping roles. Recently, GDF11 has been identified as playing a role during aging, however there are conflicting reports as to the nature of this role. In this review, we will discuss the literature regarding functions of GDF11 and myostatin in the heart, brain, and skeletal muscle during aging. Consequently we expect to develop a deeper understanding about the function of these two proteins in organismal aging and disease.

Keywords: Aging; GDF11; MSTN; Organismal aging.

Similar articles

See all similar articles

Cited by 9 articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback