Low Testosterone Levels and Metabolic Syndrome in Aging Male

Curr Pharm Des. 2017 Nov 28;23(30):4470-4474. doi: 10.2174/1381612823666170503150955.


Advances in medicine and progressive improvements in the health of the general population in developed countries have led to considerable increases in life expectancy over recent years. Metabolic syndrome (MetS) affects approximately 25% of the adult population and its prevalence is increasing all over the world. Central obesity plays an important role in emergence of MetS. Some studies have suggested that there may be link between low Total Testosterone levels and emergence of MetS. The objective of this review is to analyze the complex network of interactions between MetS and low testosterone levels in elderly men, considering etiologic, diagnostic, and therapeutic aspects. Recent evidence confirms that central obesity is the independent MetS component correlated to Total Testosterone Levels. Experimental studies suggest a two way road between Low Testosterone Levels and abdominal obesity. Besides that, Testosterone Replacement Therapy should be restricted to men with biochemical and clinical features of late onset hypogonadism.

Keywords: Low testosterone; aging male; central obesity; hypogonadism; metabolic syndrome; testosterone replacement therapy..

Publication types

  • Review

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aging / physiology*
  • Hormone Replacement Therapy / methods
  • Humans
  • Hypogonadism / drug therapy
  • Male
  • Metabolic Syndrome / epidemiology
  • Metabolic Syndrome / etiology
  • Metabolic Syndrome / physiopathology*
  • Obesity, Abdominal / complications
  • Obesity, Abdominal / epidemiology
  • Prevalence
  • Risk Factors
  • Testosterone / administration & dosage
  • Testosterone / blood*
  • Testosterone / deficiency


  • Testosterone