Susceptibility of Nosocomial Staphylococcus aureus to Chlorhexidine After Implementation of a Hospital-wide Antiseptic Bathing Regimen

Infect Control Hosp Epidemiol. 2017 Jul;38(7):873-875. doi: 10.1017/ice.2017.80. Epub 2017 May 5.

Abstract

Hospital use of chlorhexidine (CHX) containing antiseptics to decrease nosocomial infections may promote CHX resistance among pathogenic organisms. Nosocomial bloodstream-infecting Staphylococcus aureus isolates from before and after adoption of hospital-wide CHX bathing were tested for CHX susceptibility, and no decreased susceptibility or resistance-promoting genes were discovered. Infect Control Hosp Epidemiol 2017;38:873-875.

MeSH terms

  • Anti-Infective Agents, Local / pharmacology*
  • Anti-Infective Agents, Local / therapeutic use
  • Bacteremia / microbiology
  • Bacteremia / prevention & control
  • Bacterial Proteins / genetics
  • Baths / methods*
  • Chlorhexidine / pharmacology*
  • Chlorhexidine / therapeutic use
  • Cross Infection / prevention & control
  • Drug Resistance, Bacterial / genetics
  • Hospitals
  • Humans
  • Membrane Transport Proteins / genetics
  • Microbial Sensitivity Tests
  • Staphylococcal Infections / microbiology
  • Staphylococcal Infections / prevention & control
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / genetics

Substances

  • Anti-Infective Agents, Local
  • Bacterial Proteins
  • Membrane Transport Proteins
  • QacB protein, Staphylococcus aureus
  • qacA protein, Staphylococcus aureus
  • Chlorhexidine