The emerging role of mast cells in liver disease

Am J Physiol Gastrointest Liver Physiol. 2017 Aug 1;313(2):G89-G101. doi: 10.1152/ajpgi.00333.2016. Epub 2017 May 4.


The depth of our knowledge regarding mast cells has widened exponentially in the last 20 years. Once thought to be only important for allergy-mediated events, mast cells are now recognized to be important regulators of a number of pathological processes. The revelation that mast cells can influence organs, tissues, and cells has increased interest in mast cell research during liver disease. The purpose of this review is to refresh the reader's knowledge of the development, type, and location of mast cells and to review recent work that demonstrates the role of hepatic mast cells during diseased states. This review focuses primarily on liver diseases and mast cells during autoimmune disease, hepatitis, fatty liver disease, liver cancer, and aging in the liver. Overall, these studies demonstrate the potential role of mast cells in disease progression.

Keywords: cholangiopathies; disease; liver; mast cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / pathology*
  • Hepatocytes / immunology
  • Hepatocytes / pathology*
  • Humans
  • Liver / immunology
  • Liver / pathology*
  • Liver Diseases / immunology
  • Liver Diseases / pathology*
  • Mast Cells / pathology*