Alzheimer disease makes new blood contacts

Blood. 2017 May 4;129(18):2462-2463. doi: 10.1182/blood-2017-03-772087.


In this issue of Blood, Chen and colleagues demonstrate an unanticipated role for the contact system in a murine model of Alzheimer disease (AD). The study bolsters the key role of vascular dysfunction in AD by identifying factor XII (FXII) activation as a new molecular player in AD pathogenesis through mechanisms linked to cerebral fibrin deposition, neuroinflammation, and neuronal damage.

Publication types

  • Comment

MeSH terms

  • Alzheimer Disease*
  • Humans