The role of predictive vaginal biomarkers in women with cervical cerclage

J Matern Fetal Neonatal Med. 2018 Jul;31(13):1792-1797. doi: 10.1080/14767058.2017.1326895. Epub 2017 May 19.


Cervical cerclage is currently one of the primary methods of treatment for cervical insufficiency (CI). Identifying methods in order to selectively apply cerclage may allow us to further limit unnecessary procedures. In this regard, a limited number of inflammatory and extracellular matrix biomarkers measurable non-invasively at the level of the cervix have been examined. In this review we summarize the current research on the use of cervical biomarkers in predicting cerclage failure and propose potential objectives for future research.

Keywords: Cerclage; biomarkers; cervical insufficiency; preterm delivery.

Publication types

  • Review

MeSH terms

  • Biomarkers / analysis
  • Cerclage, Cervical / methods*
  • Female
  • Fibronectins / analysis
  • Humans
  • Interleukin-8 / analysis
  • Obstetric Labor, Premature / prevention & control*
  • Predictive Value of Tests
  • Pregnancy
  • Uterine Cervical Incompetence / diagnosis*
  • Uterine Cervical Incompetence / therapy
  • Vagina / physiopathology


  • Biomarkers
  • Fibronectins
  • Interleukin-8