The effects of vitamin D supplementation during pregnancy and maternal vitamin D levels on neonatal vitamin D levels and birth parameters

J Matern Fetal Neonatal Med. 2018 Jul;31(13):1727-1734. doi: 10.1080/14767058.2017.1326897. Epub 2017 May 25.

Abstract

Objective: The current study aimed to measure the levels of vitamin 25(OH)D in pregnant women and in the umbilical cord blood of newborns and to evaluate the association of vitamin D levels with birth parameters.

Methods: This cross-sectional analytic investigation was performed in 100 pregnant women at term and in 100 newborns born to these mothers. Plasma vitamin D level was measured and birth parameters of the babies were recorded.

Results: Mean vitamin D levels in pregnant women and cord blood were 11.39 ± 6.24 ng/ml and 8.00 ± 4.95 ng/ml, respectively. Vitamin D levels were found to be higher in the women who had received vitamin D support during pregnancy (p < .001). Height (p = .004), head circumference (p = .003), and chest circumference (p = .005) of newborns born to mothers who had received vitamin D support were higher compared to non-receivers. Maternal vitamin D deficiency (<10 ng/ml) and insufficiency (10-30 ng/ml) was detected in 53.0% and 47.0% of the cases, respectively. None of the women had sufficient levels of vitamin D.

Conclusions: This study established that vitamin D levels were low in maternal and cord blood in spite of the administration program of Ministry of Health in pregnant women. The importance of vitamin D supplementation should be explained to the pregnant women in each visit.

Keywords: Vitamin D; birth sizes; newborn; pregnant women; umbilical cord blood.

MeSH terms

  • 25-Hydroxyvitamin D3 1-alpha-Hydroxylase / blood*
  • Adolescent
  • Adult
  • Apgar Score
  • Birth Weight
  • Cross-Sectional Studies
  • Dietary Supplements
  • Female
  • Fetal Blood
  • Humans
  • Infant, Newborn
  • Linear Models
  • Pregnancy
  • Prenatal Nutritional Physiological Phenomena
  • Vitamin D / blood*
  • Vitamin D / therapeutic use*
  • Vitamin D Deficiency / blood*
  • Vitamin D Deficiency / epidemiology
  • Vitamin D Deficiency / prevention & control
  • Vitamins / therapeutic use*
  • Young Adult

Substances

  • Vitamins
  • Vitamin D
  • 25-Hydroxyvitamin D3 1-alpha-Hydroxylase