FlashPCA2: principal component analysis of Biobank-scale genotype datasets

Bioinformatics. 2017 Sep 1;33(17):2776-2778. doi: 10.1093/bioinformatics/btx299.


Motivation: Principal component analysis (PCA) is a crucial step in quality control of genomic data and a common approach for understanding population genetic structure. With the advent of large genotyping studies involving hundreds of thousands of individuals, standard approaches are no longer feasible. However, when the full decomposition is not required, substantial computational savings can be made.

Results: We present FlashPCA2, a tool that can perform partial PCA on 1 million individuals faster than competing approaches, while requiring substantially less memory.

Availability and implementation: https://github.com/gabraham/flashpca .

Contact: gad.abraham@unimelb.edu.au.

Supplementary information: Supplementary data are available at Bioinformatics online.

MeSH terms

  • Genetics, Population / methods*
  • Genetics, Population / standards
  • Genomics / methods*
  • Genomics / standards
  • Genotyping Techniques / methods*
  • Genotyping Techniques / standards
  • Humans
  • Principal Component Analysis*
  • Sequence Analysis, DNA / methods
  • Sequence Analysis, DNA / standards
  • Software*