Curcumin improves alcoholic fatty liver by inhibiting fatty acid biosynthesis

Toxicol Appl Pharmacol. 2017 Aug 1;328:1-9. doi: 10.1016/j.taap.2017.05.001. Epub 2017 May 2.

Abstract

Alcoholic fatty liver is a threat to human health. It has been long known that abstinence from alcohol is the most effective therapy, other effective therapies are not available for the treatment in humans. Curcumin has a great potential for anti-oxidation and anti-inflammation, but the effect on metabolic reconstruction remains little known. Here we performed metabolomic analysis by gas chromatography/mass spectrometry and explored ethanol pathogenic insight as well as curcumin action pattern. We identified seventy-one metabolites in mouse liver. Carbohydrates and lipids were characteristic categories. Pathway analysis results revealed that ethanol-induced pathways including biosynthesis of unsaturated fatty acids, fatty acid biosynthesis and pentose and glucuronate interconversions were suppressed by curcumin. Additionally, ethanol enhanced galactose metabolism and pentose phosphate pathway. Glyoxylate and dicarboxylate metabolism and pyruvate metabolism were inhibited in mice fed ethanol diet plus curcumin. Stearic acid, oleic acid and linoleic acid were disease biomarkers and therapical biomarkers. These results reflect the landscape of hepatic metabolism regulation. Our findings illustrate ethanol pathological pathway and metabolic mechanism of curcumin therapy.

Keywords: Alcoholic fatty liver; Curcumin; Fatty acid biosynthesis; Metabolomics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Central Nervous System Depressants / toxicity
  • Curcumin / therapeutic use*
  • Ethanol / toxicity
  • Fatty Acids / antagonists & inhibitors*
  • Fatty Acids / biosynthesis*
  • Fatty Liver, Alcoholic / drug therapy*
  • Fatty Liver, Alcoholic / metabolism
  • Galactose / metabolism
  • Glucuronic Acid / metabolism
  • Liver / drug effects
  • Liver / metabolism
  • Male
  • Metabolomics
  • Mice
  • Pentose Phosphate Pathway / drug effects

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Central Nervous System Depressants
  • Fatty Acids
  • Ethanol
  • Glucuronic Acid
  • Curcumin
  • Galactose