Insights into dovetailing GTD and Cancers

Crit Rev Oncol Hematol. 2017 Jun;114:77-90. doi: 10.1016/j.critrevonc.2017.04.001. Epub 2017 Apr 7.


Gestational trophoblastic diseases (GTD) encompass a group of placental tumors which mostly arise due to certain fertilization defects, resulting in the over-proliferation of trophoblasts. The major characteristic of this diseased state is that β-hCG rises up manifold than that is observed during pregnancy. The incidence of GTD when analyzed on a global scale, figures out that there is a greater risk in South-East Asia, the reason of which remains unclear. An insight into any possible correlation of GTD incidence with cancers, other than choriocarcinoma, is being attempted here. Also, we review the recent developments in research on the molecular etiopathology of GTD. This review would render a wider eye towards a new paradigm of thoughts to connect GTD and breast cancer, which has not been into the picture till date.

Keywords: Breast cancer; Cancers; GTD; Trophoblast; β-hCG.

Publication types

  • Review

MeSH terms

  • Female
  • Gestational Trophoblastic Disease / complications*
  • Gestational Trophoblastic Disease / epidemiology
  • Humans
  • Incidence
  • Neoplasms / epidemiology
  • Neoplasms / etiology*
  • Pregnancy
  • Prognosis