The hemostatic efficacy of chitosan-pads in hemodialysis patients with significant bleeding tendency

J Vasc Access. 2017 May 15;18(3):220-224. doi: 10.5301/jva.5000707. Epub 2017 Apr 28.


Background: Patients on chronic hemodialysis often have acquired coagulopathy that can aggravate bleeding from puncture site after needle extraction. Chitosan-based pads have been reported to accelerate hemostasis even in the presence of coagulopathy. The aim of this study was to evaluate the hemostatic efficacy of the chitosan pads compared to gauze pads, applied for local hemostasis.

Methods: A crossover study in a cohort of patients on hemodialysis with extended time to hemostasis after needle extraction. At the end of each dialysis, either gauze or chitosan pad was applied on both access points (arterial and venous). The type of pad was changed in the next dialysis all together 5 times in each patient (10 applications per patient for every pad).

Results: A total of 288 applications, 144 for each type of pad, were performed in 15 patients. The average time to hemostasis for the entire group was significantly shorter with the chitosan pads compared to the regular gauze pads ("arterial" point 3 vs. 18.5 min, p<0.001 "venous" access 2.8 vs. 13.2 min, p<0.001, respectively).

Conclusions: Chitosan pads significantly reduce time to hemostasis and should be considered for the treatment of accessible bleeds in patients with coagulopathy.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Bandages
  • Chitosan / administration & dosage*
  • Chitosan / adverse effects
  • Cross-Over Studies
  • Female
  • Hemorrhage / etiology
  • Hemorrhage / prevention & control*
  • Hemostatic Techniques* / adverse effects
  • Hemostatics / administration & dosage*
  • Hemostatics / adverse effects
  • Humans
  • Male
  • Middle Aged
  • Punctures / adverse effects*
  • Renal Dialysis*
  • Time Factors
  • Treatment Outcome


  • Hemostatics
  • Chitosan