Influenza Evolution: New Insights into an Old Foe

Louise H Moncla; Kelsey R Florek; Thomas C Friedrich

doi:10.1016/j.tim.2017.04.003

Influenza Evolution: New Insights into an Old Foe

Trends Microbiol. 2017 Jun;25(6):432-434. doi: 10.1016/j.tim.2017.04.003. Epub 2017 May 3.

Authors

Louise H Moncla¹, Kelsey R Florek¹, Thomas C Friedrich²

Affiliations

¹ Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine, Madison, WI 53706, USA.
² Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine, Madison, WI 53706, USA; Wisconsin National Primate Research Center, Madison, WI 53715, USA. Electronic address: thomasf@primate.wisc.edu.

PMID: 28478941
DOI: 10.1016/j.tim.2017.04.003

Abstract

Influenza viruses steadily evolve to escape detection by antibodies, necessitating vaccine updates. A new study uses a massively parallel approach, deep mutational scanning, to catalogue antibody escape mutations. This approach defines potential pathways of viral evolution, beyond those already observed in natural infections, and may help predict its future directions.

Keywords: antibody; antigenic drift; evolution; influenza.

Publication types

Comment

MeSH terms

Antibodies, Neutralizing / immunology
Antibodies, Viral / immunology
Antigens, Viral / genetics
Antigens, Viral / immunology
Evolution, Molecular*
Genetic Variation
Humans
Influenza A virus / genetics*
Influenza A virus / immunology*
Influenza Vaccines
Influenza, Human / immunology*
Influenza, Human / virology
Mutation

Substances

Antibodies, Neutralizing
Antibodies, Viral
Antigens, Viral
Influenza Vaccines