Final height and intrauterine growth retardation

Abstract

Approximately 10% of small for gestational age (SGA) children maintain a small body size throughout childhood and often into adult life with a decreased pubertal spurt. Growth hormone (GH) therapy increases short-term growth in a dose-dependent manner and adult height had now been well documented. Shorter children might benefit from a higher dose at start (50μg/kg/day). The response to GH treatment was similar for both preterm and term short SGA groups and the effect of GH treatment on adult height showed a wide variation in growth response. As a whole, mean adult height is higher than -2 SDS in 60% of patients and 70% reached an adult height in their target height with better results with higher doses and combined GnRH analog therapy in those who were short at onset of puberty.

Keywords: Adult height; Final height; Growth hormone treatment (GH); Intrauterine growth retardation (IUGR); Petit pour l’âge gestationnel; Retard de croissance intra-utérin (RCIU); Small for gestational age (SGA); Taille adulte; Taille finale; Traitement par hormone de croissance.