Specialized pro-resolving mediators in renal fibrosis

Mol Aspects Med. 2017 Dec;58:102-113. doi: 10.1016/j.mam.2017.05.001. Epub 2017 May 11.

Abstract

Inflammation and its timely resolution play a critical role in effective host defence and wound healing. Unresolved inflammatory responses underlie the pathology of many prevalent diseases resulting in tissue fibrosis and eventual organ failure as typified by kidney, lung and liver fibrosis. The role of autocrine and paracrine mediators including cytokines, prostaglandins and leukotrienes in initiating and sustaining inflammation is well established. More recently a physiological role for specialized pro-resolving lipid mediators [SPMs] in modulating inflammatory responses and promoting the resolution of inflammation has been appreciated. As will be discussed in this review, SPMs not only attenuate the development of fibrosis through promoting the resolution of inflammation but may also directly suppress fibrotic responses. These findings suggest novel therapeutic paradigms to treat intractable life-limiting diseases such as renal fibrosis.

Keywords: Chronic kidney disease; Diabetic kidney disease; Specialized pro-resolving mediators.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers
  • Disease Progression
  • Fibrosis
  • Gene Expression Regulation
  • Humans
  • Inflammation Mediators / metabolism*
  • Inflammation Mediators / therapeutic use
  • Kidney Diseases / drug therapy
  • Kidney Diseases / etiology*
  • Kidney Diseases / metabolism*
  • Kidney Diseases / pathology
  • Lipid Metabolism
  • Liver Cirrhosis / drug therapy
  • Liver Cirrhosis / etiology
  • Liver Cirrhosis / metabolism
  • Liver Cirrhosis / pathology
  • Pulmonary Fibrosis / drug therapy
  • Pulmonary Fibrosis / etiology
  • Pulmonary Fibrosis / metabolism
  • Pulmonary Fibrosis / pathology
  • Signal Transduction

Substances

  • Biomarkers
  • Inflammation Mediators