Mucinous islet cell (amphicrine) carcinoma of the pancreas associated with watery diarrhea and hypokalemia syndrome

Hum Pathol. 1988 Dec;19(12):1458-61. doi: 10.1016/s0046-8177(88)80240-5.


A case of mucinous islet cell carcinoma associated with watery diarrhea and hypokalemia syndrome is reported. Electron microscopic and immunohistochemical studies demonstrated mucigen granules and endocrine features in the tumor cells. The significance of the findings with regard to the histogenesis and diagnosis of this rare neoplasm is discussed.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma, Islet Cell / complications
  • Adenoma, Islet Cell / ultrastructure*
  • Diarrhea / etiology*
  • Female
  • Humans
  • Hypokalemia / etiology*
  • Immunoenzyme Techniques
  • Middle Aged
  • Pancreatic Neoplasms / complications
  • Pancreatic Neoplasms / ultrastructure*
  • Pancreatic Polypeptide / analysis
  • Syndrome


  • Pancreatic Polypeptide